March 2023 Update:
March 31st, 2023, marked a significant milestone for CODE-MI as the project’s enrolment phase came to a conclusion. With 24 sites and 17 clusters, in 8 provinces, the study now enters the follow up phase of two years, ending on March 31st, 2025.
We appreciate the continued support of all the sites and look forward to completing the final stage of CODE-MI.
March 2022 Update:
As of March 2022, we have 20 sites and 14 clusters which have either initiated the study intervention or are scheduled to switch by March 15th. We are aiming to have all sites switched by end of April.
Over the coming months, we will be in touch with each province to discuss the data access process. A reminder that no data will be extracted/accessed until the study’s 1-year follow-up has been completed – which at this point is estimated to be around July 2023.
Thank you for all your efforts and patience during this challenging time,
December 2021 Update:
As of December 2021, 12 sites have implemented the study intervention and several more sites are expected to begin in January 2022.
September 2020: CODE-MI Trial Resumption and Design Manuscript Publication
Message from Dr. Humphries sent to all study leads on September 23, 2020:
“The past 6 months have been challenging, given the need to shut down the trial due to COVID. And now there are concerns with a 2nd wave. We have successfully started CODE-MI at two sites – St. Paul’s Hospital in Vancouver, Regina General Hospital in Saskatchewan – and are preparing to initiate five additional sites in the coming weeks to months, if COVID remains manageable. As per protocol, all sites will be notified 6-8 weeks prior to the initiation date, once all their approvals are in place.
We have been in touch with several sites to gauge their readiness to start CODE-MI again. Given that there is no patient contact or de novo data collection, several sites have indicated their willingness to resume. We continue to follow-up with these sites, and will monitor the COVID-19 situation as significant numbers of new cases have been reported in several parts of the country.
Many of you have continued to work on your ethics and contracts during the shutdown and we are now pleased to report that all sites have completed their ethics submissions; we are waiting on approval from Quebec and several sites are now submitting renewals. Some sites have also completed their contracts, and many more are close to signing off.
We are continuing our conversations with CIHI and DASH-HDRN (Data Access Support Hub- Health Data Research Network) to work out the details regarding data sharing across provinces. So far things are progressing well, but several details still need to be worked out. Thankfully, data analysis aspects doesn’t occur until late 2023, so we have time to finalize all the details.
I am also delighted to report that our trial design paper has now been published in American Heart Journal https://doi.org/10.1016/j.ahj.2020.06.013.”
March 2020: CODE-MI Trial Temporarily Suspend Due to COVID-19
Message from Dr. Humphries sent to all study leads on March 19, 2020:
“Given the unprecedented situation facing everyone at this time, the CODE-MI team has decided to temporarily suspend the trial. The plan was to have 5 sites implement the study in July, but given the challenges facing the healthcare system, and the key role of the emergency departments in the evolving pandemic, now is not the time to conduct a clinical trial.
We would ask the sites that are still working on ethics, departmental approvals, and agreements to please continue. We are here to support you and answer any questions that arise.
For many of our CODE-MI collaborators who provide patient care, we extend our thoughts and best wishes for your safety and health. Like you, we will continue to monitor the situation and we will reach out again once things have begun to settle, which they will.
We have submitted the CODE-MI study design manuscript to the American Heart Journal, and we are finalizing our feasibility study paper, with our colleagues in Toronto.
We look forward to re-launching CODE-MI trial when the current COVID-19 situation resolves.
Stay safe and stay healthy, The CODE-MI Team in Vancouver”
February 2020: CODE-MI Launched!
In late December 2019, the first two CODE-MI sites were informed that they had been selected to implement the lower female-specific cut-point.
On February 8th 2020, St. Paul’s Hospital in Vancouver implemented the new cut-point. Regina General Hospital will be implementing shortly as well.
Ethics approvals:
All participating provinces have received REB approvals.